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目的:探讨苯磺酸氨氯地平片治疗轻中度高血压的临床疗效与药理分析。方法:选择2015年3月至2016年3月在珠海市第五人民医院治疗的140例轻中度高血压患者,随机分为两组。对照组采用硝苯地平治疗,观察组采用苯磺酸氨氯地平片治疗,3个月后比较两组患者的治疗效果、血压及心率、安全性。结果:观察组治疗有效率为95.71%,明显高于对照组84.29%,差异具有统计学意义(P<0.05);观察组治疗后收缩压、舒张压改善明显优于对照组,差异具有统计学意义(P<0.05);治疗前后两组心率均无明显变化(P>0.05);观察组不良反应发生率与对照组相比明显降低(P<0.05)。结论:苯磺酸氨氯地平片治疗轻中度高血压有确切的临床疗效,血压控制平稳,药效稳定,无明显的不良反应,患者耐受性好。
Objective: To investigate the clinical efficacy and pharmacological analysis of amlodipine besylate in the treatment of mild to moderate hypertension. Methods: A total of 140 mild to moderate hypertensive patients treated in Zhuhai No. 5 People’s Hospital from March 2015 to March 2016 were randomly divided into two groups. The control group was treated with nifedipine. The observation group was treated with amlodipine besylate tablets. The therapeutic effect, blood pressure, heart rate and safety were compared between the two groups after 3 months. Results: The effective rate of observation group was 95.71%, which was significantly higher than that of control group (84.29%), the difference was statistically significant (P <0.05); the systolic blood pressure and diastolic blood pressure of observation group improved obviously better than that of control group (P <0.05). There was no significant difference in heart rate between the two groups before and after treatment (P> 0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P <0.05). Conclusion: Amlodipine besylate tablets for the treatment of mild to moderate hypertension have the exact clinical curative effect, stable blood pressure control, stable efficacy, no obvious adverse reactions, patients with good tolerance.