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用一种或两种药物治疗HP感染的根治率低于50%,而三联疗法显示根除率>50%,本文评估三联疗法根除HP感染的疗效及其影响因素。材料和方法:十二指肠溃疡70例,胃溃疡17例和胃炎6例,三种抗菌药物为四环素(500mg qid)、灭滴灵(250 mg tid)和次水杨酸铋(每餐时服1或2片,临睡2片,每片150mg)。疗程分为10、14和28天三组。全部病例应用[~(13)C]尿素呼吸试验和ELISA法证实HP状态。82%患者在治疗前活检胃窦粘膜作HP培养、银染色组织学检查,随访是通过内镜活检胃窦粘膜、呼吸试验及血清学检查。根治是指治疗结束后≥1月,无HP存在。结果:93例受试者经4～79周随访(中位数为29周)结果表明总根除率为87%,不同治疗组的根除率为70～100%,无显著性差异,10天、14天和28天的根除率分别为77%、91%和86.6%,其间也无显著性差异。
The cure rate of HP infection with one or two drugs is less than 50%, while the triple therapy shows eradication rate> 50%. This article assesses the efficacy of triple therapy in eradicating HP infection and its influencing factors. MATERIALS AND METHODS: 70 cases of duodenal ulcer, 17 cases of gastric ulcer and 6 cases of gastritis. The three antibiotics were tetracycline (500 mg qid), metronidazole (250 mg tid) and bismuth subsalicylate 1 or 2 servings, sleeps 2, 150mg each). The treatment was divided into three groups of 10, 14 and 28 days. All cases [~ (13) C] urea breath test and ELISA confirmed HP status. 82% of patients were biopsied antral mucosa before treatment for HP culture, silver staining histological examination, follow-up by endoscopic biopsy of antral mucosa, respiratory tests and serological tests. Radical refers to ≥ 1 month after the end of treatment, no HP exists. Results: The 93 patients were followed up for 4-79 weeks (median 29 weeks). The results showed that the total eradication rate was 87% and the eradication rates were 70-100% in different treatment groups. There was no significant difference between the two groups. After 10 days, The eradication rates at 14 days and 28 days were 77%, 91% and 86.6% respectively, with no significant difference between them.