本文应用四株人体肿瘤细胞株作为靶细胞,比较了云芝糖肽PSP与PSK在体外对它们的作用。结果表明PSP与PSK的抗癌生物活性基本相同,二者均对靶细胞增殖具有中等抑制作用。PSP在1000μg/ml的浓度时对人肺腺癌细胞株(SPC)仍能引起一系列的形态学异常变化,如细胞肿大,核染色质凝聚,锯齿状核和多核现象。 In this study, four human tumor cell lines were used as target cells to compare the effect of PSK and PSK of P. yunnanensis on them. The results showed that the anti-cancer biological activity of PSP and PSK is basically the same, both of which have a moderate inhibitory effect on the proliferation of target cells. PSP can still cause a series of morphological abnormalities in human lung adenocarcinoma cell lines (SPC) at a concentration of 1000 μg/ml, such as cell enlargement, nuclear chromatin condensation, jagged nucleus and multinuclear phenomena.