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目的探讨宫颈阴道分泌物中可溶性细胞间黏附分子-1(sICAM-1)预测早产的价值。方法2005年1月至2007年4月在吉首大学第一附属医院,选择先兆早产(62例)与同期正常孕妇(58例)共120例,应用酶联免疫法检测其宫颈阴道分泌物中sICAM-1的含量,并追踪其妊娠结局。结果先兆早产组、正常妊娠组sICAM-1的质量浓度分别为(49.80±33.61)μg/L和(32.82±22.95)μg/L;早产者、足月产者sICAM-1的质量浓度分别为(69.48±31.98)μg/L和(28.17±17.24)μg/L,两组差异有统计学意义(P<0.05);宫颈阴道分泌物sICAM-1的质量浓度35.54μg/L为预测早产的最佳界限值。结论宫颈阴道分泌物中sICAM-1有望成为早产预测的有效指标。
Objective To investigate the value of soluble intercellular adhesion molecule-1 (sICAM-1) in cervical vaginal secretion in predicting preterm delivery. Methods From January 2005 to April 2007, a total of 120 cases of preeclampsia (62 cases) and normal pregnant women (58 cases) were enrolled in the First Affiliated Hospital of Jishou University. The sICAM in cervical vaginal secretions was detected by enzyme-linked immunosorbent assay -1 content, and track its pregnancy outcome. Results The serum concentrations of sICAM-1 in preterm preterm group and normal pregnancy group were (49.80 ± 33.61) μg / L and (32.82 ± 22.95) μg / L, respectively. The sICAM- 69.48 ± 31.98) μg / L and (28.17 ± 17.24) μg / L, respectively. There was significant difference between the two groups (P <0.05). The concentration of sICAM-1 in cervical vaginal secretions was 35.54μg / L, Boundary value. Conclusion Cervical vaginal secretions of sICAM-1 is expected to be an effective predictor of preterm birth.