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目的 :为观察与研究 1998年长江流域抗洪期间 ,联合应用青蒿琥酯与吡喹酮预防抗洪官兵的血吸虫感染的效果。方法 :对某部参加抗洪抢险官兵 136 2人定期给予青蒿琥酯和吡喹酮口服 ,另以未服药的 112名抗洪人员作为对照 ,在同一时期采集两组人员的血清标本 ,用循环抗原酶联免疫 (双夹心ELISA法 )及乳胶凝集实验检测日本血吸虫抗体 (乳胶法 )检测两组人员血吸虫感染情况。结果 :服药组血吸虫病感染率 1.6 2 % ,对照组血吸虫病感染率 14.2 9% ,经统计学处理 ,二者有非常显著性差异 (P <0 .0 1)。结论 :青蒿琥酯与吡喹酮联合应用 ,具有良好的预防血吸虫病的效果 ,且在服药的官兵中未发现明显的不良反应。对抗洪抢险人员采取科学的药物预防措施是十分必要的。
OBJECTIVE: To observe and study the effect of artesunate and praziquantel in preventing schistosomiasis infection among officers and men of anti-flood during the flood control in the Yangtze River Basin in 1998. Methods: A group of 136 officers and soldiers participating in flood fighting and rescue operations were given oral administration of artesunate and praziquantel on a regular basis. Another 112 flood-fighting officers, who were not taking medication, were taken as control. Serum samples from two groups were collected during the same period, Enzyme-linked immunosorbent assay (ELISA) and latex agglutination test were used to detect Schistosoma japonicum antibody (latex method). Results: The infection rate of schistosomiasis was 1.6 2% in the medication group and 14.2 9% in the control group. There was a significant difference between the two groups (P <0.01). Conclusion: The combination of artesunate and praziquantel has a good effect of preventing schistosomiasis, and no obvious adverse reactions were found in the officers and soldiers taking the drug. It is necessary to take scientific preventive measures against flood and rescue workers.