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目的探索广西白裤瑶族地区人群心理应激状况及其对人热休克蛋白70(Heat Shock Protein 70,HSP70)的影响。方法采用随机整群抽样法,应用生活事件量表(LES)、简化症状自评量表(SCL-90)、和社会支持评定量表(SSRS)对广西南丹县白裤瑶和壮族人群324人进行问卷调查,同时应用ELISA法测量血样中HSP70的含量。结果 (1)调查对象的生活事件总分≥20分占32.41%,心理问题阳性检出率为26.12%;社会支持总均分为(8.55±1.69)分。壮族人群的焦虑水平为(1.66±0.69)分,高于白裤瑶族(1.43±0.42)分(P<0.05)。(2)被试者HSP70表达水平在(1.43±0.15)Lg/ml范围,不同民族之间差异有统计学差异。(3)全体调查对象HSP70表达水平与年龄(r=-0.211,P<0.05)和焦虑呈负相关(r=-0.216,P<0.05);与文化程度(r=0.318,P<0.001)和社会支持呈正相关(r=0.181,P<0.05);采取分层回归分析对文化程度和年龄进行变量控制,壮族人群的社会支持对HSP70表达呈正相关影响(β=0.263)。结论广西白裤瑶人群的心理应激和心理卫生状况不容乐观,HSP70表达与焦虑和社会支持等心理因素有相关性。
Objective To explore the psychological stress status and its effect on heat shock protein 70 (HSP70) in Baiku Yao ethnic group in Guangxi province. Methods A random cluster sampling method was used to analyze the prevalence of Baikuyao and Zhuang nationality 324 in Nandan County, Guangxi Province using the Life Events Scale (LES), the Simplified Symptom Checklist 90 (SCL-90) and the Social Support Rating Scale (SSRS) People conducted a questionnaire survey, while the application of ELISA method to measure the content of HSP70 in blood samples. Results (1) The total score of life events of the surveyed subjects was ≥20, accounting for 32.41%. The positive rate of psychological problems was 26.12%. The total social support was (8.55 ± 1.69) points. The level of anxiety in Zhuang was (1.66 ± 0.69) points higher than that in Baiku Yao (1.43 ± 0.42) points (P <0.05). (2) Subjects HSP70 expression level (1.43 ± 0.15) Lg / ml range, there are significant differences between different ethnic groups. (3) There was a negative correlation between the expression level of HSP70 and age (r = -0.211, P <0.05) and anxiety (r = -0.216, P < Social support was positively correlated with social support (r = 0.181, P <0.05). By stratified regression analysis, the level of education and age were controlled by variables. The social support of Zhuang people had a positive correlation with the expression of HSP70 (β = 0.263). Conclusions Psychological stress and mental health conditions in Baiku Yao are not optimistic. HSP70 expression is associated with psychological factors such as anxiety and social support.