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1984年,Russell等在大鼠血浆中发现一种可刺激大鼠肝脏DNA合成的阳离子交换剂多肽,并称之为肝细胞生长因子(HGF)。在随后的20余年中,人们对HGF的研究不断深入,目前认为HGF是一种多效性细胞因子,在促有丝分裂、细胞移动、血管生成、造血、抗凋亡、抗纤维化、修复组织损伤和抑制肿瘤细胞生长等多方面发挥重要生物学功能。在正常成年动物的所有器官中,HGF在肾脏的表达水平最高,约为肝脏的4倍,其受体c-met在肾脏中的表达水平也很高。近年来HGF及其受体在肾脏疾病中的作用受到了广泛关注。
In 1984 Russell et al. Found a cationic exchanger polypeptide that stimulates rat liver DNA synthesis in rat plasma and called it hepatocyte growth factor (HGF). In the following 20 years, people’s research on HGF has been deepened. At present, HGF is thought to be a pleiotropic cytokine, which has the functions of promoting mitosis, cell migration, angiogenesis, hematopoiesis, anti-apoptosis, anti-fibrosis, And inhibit tumor cell growth and many other important biological functions. In all organs of normal adult animals, HGF has the highest level of expression in the kidney, which is about four times that of the liver, and the expression level of its receptor c-met in the kidney is also high. In recent years, the role of HGF and its receptors in renal diseases has received widespread attention.