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目的:探讨三氧化二砷治疗晚期胰腺癌的临床疗效。方法:采用经泵区域性动脉灌注0.1%三氧化二砷,剂量10~20mg.d-1,持续用药7d为一个疗程,4周后重复。结果:实验组中,临床受益反应为有效的为14人,稳定的7人,总有效率为80.8%。病灶情况为完全缓解的有4人,部分缓解的有12人,总有效率为61.5%。患者中位生存时间为12.1月。结论:三氧化二砷治疗晚期胰腺癌,临床效果明显,能减轻患者症状,毒副作用小,应用前景广阔。
Objective: To investigate the clinical efficacy of arsenic trioxide in the treatment of advanced pancreatic cancer. Methods: Regional arterial infusion of 0.1% arsenic trioxide, dose of 10 ~ 20mg.d-1, continued treatment for 7d for a course of treatment, 4 weeks after the repeat. Results: In the experimental group, the clinical benefit response was 14 and stable, the total effective rate was 80.8%. 4 cases of complete remission of lesions, 12 cases of partial remission, the total effective rate was 61.5%. The median survival time was 12.1 months. Conclusion: Arsenic trioxide in the treatment of advanced pancreatic cancer has obvious clinical effect, can alleviate the symptoms of patients, has little toxic and side effects and has broad application prospects.