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目的研究纹状体边缘区与脑内其他与学习记忆有关脑区间的关系。方法高频刺激穿通纤维-齿状回通路在海马诱发长时程增强(LTP),观察海人藻酸毁损纹状体边缘区后对海马LTP的影响。结果高频刺激穿通通路后,正常组和盐水对照组的群体峰电位幅度显著增加;毁损组动物在高频刺激后,群体峰电位增加幅度明显低于正常组和盐水对照组,毁损组的兴奋性突触后电位也明显低于正常组和盐水对照组。表明毁损边缘区后海马LTP明显降低。结论毁损纹状体边缘区后对海马LTP的形成有一定影响。
Objective To study the relationship between the marginal division of the striatum and other brain-related brain regions in learning and memory. Methods The long-term potentiation (LTP) induced by high-frequency stimulation of the penetrating fiber-dentate gyrus in the hippocampus was used to observe the effect of kainic acid on the LTP in the hippocampus after it damaged the striatum. Results After high-frequency stimulation of the punch-through pathways, the amplitude of peak potential of the normal group and saline control group increased significantly. The amplitude of peak increase in the damaged group was significantly lower than that of the normal group and saline control group Sex post-synaptic potential was also significantly lower than the normal group and saline control group. The LTP of the hippocampus in the marginal zone was significantly decreased. Conclusions Damage to the marginal division of striatum may affect the formation of LTP in the hippocampus.