线粒体对细胞程序化死亡有调控作用。程序化死亡细胞可观察到线粒体转膜电位的下降,线粒体通透性改变很可能是细胞程序化死亡链条中的关键,由此导致程序化死亡诱导因子的释放。Bcl-2基因也与线粒体的调控密切相关。对于线粒体功能和细胞程序化死亡关系的研究,深化了对细胞程序化死亡的认识。 Mitochondria regulate programmed cell death. A decrease in mitochondrial transmembrane potential is observed in programmed death cells, and changes in mitochondrial permeability are likely to be key in the chain of apoptosis, resulting in the release of programmed death-inducing factors. Bcl-2 gene is also closely related to the regulation of mitochondria. The study of the relationship between mitochondrial function and programmed cell death deepens the understanding of programmed cell death.