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目的评价血清肿瘤标记物联合检测对胃癌和大肠癌诊断和监测的价值。方法用 PC-12多种肿瘤标志物蛋白芯片检测系统检测179例胃癌和大肠癌患者、82例胃和结直肠良性疾病患者及160例健康人血清中12种常见肿瘤标志物GA19-9、NSE、CEA、CA242、铁蛋白(Ferritin)、Beta- HCG、AFP、free-PSA、PSA、CA125、HGH、CA153的水平。结果肿瘤组的肿瘤标志物水平显著高于良性疾病组及健康组(P<0．01),其中CA19-9、CEA、CA242、CA125和CA153 5项在胃癌和大肠癌患者中水平较两对照组明显升高,差异有统计学意义(P<0．01)。采用平行检测法,可以提高检测的敏感度(72．07％)和阴性预测值(79．25％);采用系列检测,可提高检测的特异度(92．15％)和阳性预测值(84．67％)。肿瘤根治术后,肿瘤标记物水平显著下降。术后未降至正常者,复发或转移率为 68．89％,而术后再升高者复发或转移率为77．78％。结论多种肿瘤标记物对胃癌和大肠癌的诊断、监测肿瘤复发和转移有一定的价值。
Objective To evaluate the value of combined detection of serum tumor markers in the diagnosis and monitoring of gastric cancer and colorectal cancer. Methods A total of 179 tumor markers of gastric cancer and colorectal cancer, 82 patients with benign disease of stomach and colorectal and 160 healthy volunteers were enrolled in this study. The detection of 12 common tumor markers, GA19-9, NSE , CEA, CA242, Ferritin, Beta- HCG, AFP, free-PSA, PSA, CA125, HGH, CA153. Results The levels of tumor markers in tumor group were significantly higher than those in benign disease group and healthy group (P <0.01). The levels of CA19-9, CEA, CA242, CA125 and CA153 in gastric cancer and colorectal cancer were significantly higher than those in two control Group was significantly higher, the difference was statistically significant (P <0.01). The parallel detection method can improve the detection sensitivity (72.07%) and negative predictive value (79.25%), and the series detection can improve the detection specificity (92.15%) and the positive predictive value .67%). After radical nephrectomy, tumor marker levels decreased significantly. The recurrence or metastasis rate was 68.89% after the operation, but the recurrence or metastasis rate was 77.78% after the operation. Conclusion A variety of tumor markers for gastric cancer and colorectal cancer diagnosis, monitoring tumor recurrence and metastasis have some value.