【摘 要】
：
As a member of ING gene family which harbor the PHD domain and NLS domain, ING4 was reported to interact with tumor suppressor p53 and found to be involved
【机 构】
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Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China
【出 处】
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第八次全国医学遗传学学术会议(中华医学会2009年医学遗传学年会)
论文部分内容阅读
As a member of ING gene family which harbor the PHD domain and NLS domain, ING4 was reported to interact with tumor suppressor p53 and found to be involved in various biological activities, including cell cycle arrest, regulation of gene transcription, DNA repair and apoptosis.ING4_vl was located in nucleus whereas other three variants were located in cytoplasm.To clarify the role of ING4 in human stomach adencarcinoma, we first compared ING4 expression in four human gastric adenocarcinoma cell lines by RT-PCR and Real-time PCR.Low ING4 mRNA level was found in all cell lines, while there was lower ING4 expression found in poorly differentiated cell lines.
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