Combination of lenalidomide and bortezomib triggers in vitro and in vivo synergistic cytotoxicity on

来源 :22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会) | 被引量 : 0次 | 上传用户：my_code

【摘要】

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【作者】

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Zheng-Zi Qian Hua-Qing Wang

【机构】

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Department of lymphoma,Tianjin Medical University Cancer Hospital,Sino-US center for lymphoma and le

【出处】

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22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会)

【发表日期】

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2013年7期

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Objective: To evaluate the antitumor effect of lenalidomide(LEN) in combination with bortezomib (BTZ) on T-cell lymphoma cells and their microenvironment.The synergistic or antagonistic effects of the two drugs and their mechanisms of action were determined.Methods: Established T-cell lymphoma HUT-78 cells and freshly isolated tumor cells from patients with relapsed or refractory T-cell lymphoma were separately treated with LEN or BTZ or a combination of the two drugs (LEN/BTZ) for 48 h in vitro.

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