论文部分内容阅读
目的 观察三维适形放射治疗 (3DCRT)配合化疗治疗局部晚期非小细胞肺癌的耐受性及近期疗效。方法 2 4例局部晚期非小细胞肺癌 (Ⅲa或Ⅲb期 )患者进入三维适形放射治疗加化疗组 ,全部患者均行NP方案 (N :去甲长春花碱 2 5mg/m2 第 1、8天给予 ;P :顺铂 6 0～ 80mg/m2 第 1天或分 2～ 3d给予 ;2 1d为 1个周期 )化疗加 3DCRT同步治疗。结果 2 4例全部完成治疗计划 ,肺原发灶完全缓解 (CR)占 16 .7% ,部分缓解 (PR)占 75 .0 % ,无变化和进展 (NR +PD)占 8.3% ,总有效 (CR +PR)率为 91.7% ;纵隔转移淋巴结完全缓解 (CR)占 36 .4 % ,部分缓解 (PR)占 6 3.6 % ,无变化和进展(NR +PD)占 0 % ,总有效 (CR +PR)率为 10 0 %。白细胞下降发生率为 95 .8% ,其中 3、4级白细胞下降为 5 4 .2 % ;放射性食管炎和放射性肺炎的发生率分别为 5 4 .2 %和 12 .5 % ,均为 1、2级。结论 三维适形放射治疗配合化疗治疗局部晚期非小细胞肺癌能为绝大多数患者耐受 ,有较好的近期疗效。
Objective To observe the three-dimensional conformal radiotherapy (3DCRT) in combination with chemotherapy for the treatment of locally advanced non-small cell lung cancer and its recent efficacy. Methods Twenty-four patients with locally advanced non-small cell lung cancer (stage Ⅲa or Ⅲb) entered the three-dimensional conformal radiotherapy plus chemotherapy group, and all the patients underwent NP regimen (N: norvincaleutine 25mg / m2 on days 1 and 8 Given; P: cisplatin 60 ~ 80mg / m2 day 1 or 2 ~ 3d to give; 2d for 1 cycle) chemotherapy plus 3DCRT synchronization. Results Twenty-four patients completed complete treatment. The complete remission (CR) accounted for 16.7%, partial remission (PR) 75.0%, and no change and progression (NR + PD) 8.3% (CR + PR) was 91.7%; CR was 36.4%, PR was 6 3.6%, NR + PD was 0%, and the total effective rate was CR + PR) rate of 10%. The incidence of leukopenia was 95.8%, of which the grade 4 leukocytes decreased to 5.22%. The incidences of radiation esophagitis and radiation pneumonitis were 54.2% and 12.5% respectively, both of which were 1, level 2. Conclusion Three-dimensional conformal radiotherapy combined with chemotherapy for the treatment of locally advanced non-small cell lung cancer can tolerate the vast majority of patients with good short-term efficacy.