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目的探讨甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原724(CA724)、糖类抗原125(CA125),联合检测对常见恶性肿瘤的诊断作用。方法应用电化学发光法联合检测AFP、CEA、CA199 CA724、CA125,在各种常见恶性肿瘤中的含量,比较其相应的敏感性和特异性。结果肝癌患者AFP及CA199、CA724敏感性高。肺癌CEA、CA125明显升高。大肠癌患者CEA及CA199明显升高。胰腺癌CA199、CA724明显升高。卵巢癌中CA125、CA199明显升高。与其他良性疾病组及健康对照组比较,差异有统计学意义。结论联合检测肿瘤标志物有助于提高常见恶性肿瘤的早期检出率。
Objective To investigate the diagnostic value of combined detection of AFP, CEA, CA199, CA724 and CA125 in the diagnosis of common malignant tumors. Methods The levels of AFP, CEA, CA199, CA724 and CA125 in various common malignant tumors were detected by electrochemiluminescence and the corresponding sensitivity and specificity were compared. Results AFP and CA199, CA724 in HCC patients were highly sensitive. Lung cancer CEA, CA125 was significantly higher. Patients with colorectal cancer CEA and CA199 was significantly higher. Pancreatic cancer CA199, CA724 was significantly higher. Ovarian cancer CA125, CA199 was significantly higher. Compared with other benign disease group and healthy control group, the difference was statistically significant. Conclusion Combined detection of tumor markers can help improve the early detection rate of common malignant tumors.