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目的 探讨泼尼松“拖尾疗法”治疗频繁复发的原发性肾病综合征的疗效及其与组织病理学变化的关系。方法 对 5 6例行肾穿刺且随访到位的患者在行“拖尾疗法”的同时 ,按其是否接受环磷酰胺冲击治疗 (CTX-PT)分组 ,分别观察其疗效与组织病理学变化的关系。结果 病理表现为单纯微小病变、轻微病变或系膜增生性肾炎的 30例频繁复发原发性肾病综合征者应用拖尾疗法的同时按是否联用 CTX- PT分组观察疗效 ,两组均未再发 ,无统计学意义。伴肾小管间质损害的 2 6例中 ,联用 CTX- PT 1 2例 ,复发 2例 ;未联用 CTX- PT 1 4例 ,复发 8例 ;两组有显著性差异 (P<0 .0 5 )。结论 “拖尾疗法”可降低原发性肾病综合征复发的频率 ,伴有肾小管间质损害者联用 CTX- PT复发频率明显低于单纯接受“拖尾疗法”者
Objective To investigate the curative effect of prednisone “tail-tailed therapy” on patients with recurrent nephrotic syndrome and its relationship with histopathological changes. Methods Fifty-six patients undergoing renal biopsy with follow-up were divided into two groups according to whether they received CTX-PT or not. The curative effect and histopathological changes were observed respectively . Results Thirty patients with recurrent primary nephrotic syndrome with minimal or mild or mesangial proliferative glomerulonephritis were treated with trailing therapies at the same time according to CTX-PT or not, while no effect was observed in either group Hair, no statistical significance. Among the 26 cases with tubulointerstitial injury, 2 cases were combined with CTX-PT and 2 cases were relapsed; 4 cases were not combined with CTX-PT and 8 cases were relapsed. There were significant differences between the two groups (P <0. 0 5). Conclusion “Tailing therapy” can reduce the recurrence of primary nephrotic syndrome frequency, with tubulointerstitial damage associated with CTX-PT recurrence frequency was significantly lower than those who simply accept “trailing therapy” who