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目的:研究云实皮抗炎活性部位的化学成分。方法:采用硅胶柱色谱及Sephadex LH-20等色谱技术分离纯化,根据理化性质及波普数据鉴定结构。结果:从云实皮的醇提物活性部位分离得到9个化合物,结构鉴定为:(±)原苏木素B(1),东莨菪亭-7-O-β-D-吡喃葡萄糖苷(2),4-羟基-3-甲氧基苯-1-O-β-D-吡喃葡萄糖苷(3),(1’R,3’S,5’R,8’S,2Z,4E)-二氢红花菜豆酸-3’-O-β-D-吡喃葡萄糖苷(4),(1’R,3’S,5’R,8’S,2E,4E)-二氢红花菜豆酸-3’-O-β-D吡喃葡萄糖苷(5),甘草素(6),异莨菪亭(7),7-羟基-3-(4’-羟基亚苄基)-色原-4-酮(8),3-去氧苏木查尔酮(9)。结论:化合物2~5,7为首次从该属植物中分离得到,6,8为首次从云实中分离的到。
Objective: To study the chemical constituents of the anti-inflammatory active site Methods: The constituents were separated and purified by silica gel column chromatography and Sephadex LH-20 chromatography. The structures were elucidated on the basis of physico-chemical properties and Popper’s data. Results: Nine compounds were isolated from the active fractions of the alcoholic extract from the stems of Fagus incognita. The structures of the compounds were identified as: (±) hematoxylin B (1), scopolamine-7-O-β-D-glucopyranoside ), 4-hydroxy-3-methoxybenzene-1-O-β-D-glucopyranoside (3), (1’R, 3’S, 5’R, 8’S, 2Z, 4E) (4’), (1’R, 3’S, 5’R, 8’S, 2E, 4E) -drunacin-3’-O -glucopyranoside (5), glycyrrhizin (6), scopolamine (7), 7-hydroxy-3- (4’-hydroxybenzylidene) , 3-deoxyxamine chalcone (9). Conclusion: Compounds 2 ~ 5 and 7 were isolated from this genus for the first time, while 6 and 8 were isolated from the cloud for the first time.