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目的 氯沙坦钾对糖尿病肾病慢性肾功能不全患者肾功能的影响。方法 糖尿病肾病并慢性肾功能不全的高血压患者17例,停用抗高血压药物,安慰剂治疗2周后,应用氯沙坦钾治疗8周,观察患者血尿素氮、血肌酐、24h尿蛋白量、肌酐清除率、电解质、尿酸及血压变化。结果 氯沙坦钾治疗后患者血压显著下降(P<0.01)、尿蛋白排出量减少、肌酐清除率明显升高(P<0.01),而不伴有心率与体重的改变。同时患者的电解质、尿量无明显变化(P>0.05)。结论 氯沙坦钾在对糖尿病肾病慢性肾功能不全高血压患者有效降低血压的同时,对患者的肾功能有保护作用。
Effect of Losartan on Renal Function in Patients with Diabetic Nephropathy Chronic Renal Insufficiency. Methods Seventeen patients with diabetic nephropathy and chronic renal insufficiency were treated with antihypertensive drugs. After two weeks of placebo treatment, they were treated with losartan potassium for 8 weeks. Blood urea nitrogen, serum creatinine, 24h urinary protein Volume, creatinine clearance, electrolytes, uric acid and blood pressure changes. Results After losartan potassium treatment, blood pressure decreased significantly (P <0.01), urinary protein excretion decreased and creatinine clearance rate increased significantly (P <0.01), but not associated with heart rate and body weight changes. At the same time the patient’s electrolyte, urine volume did not change significantly (P> 0.05). Conclusion Losartan in diabetic nephropathy patients with chronic renal insufficiency effectively reduce blood pressure in patients with renal function has a protective effect.