目的探讨CK19、MUC2在结直肠印戒细胞癌原发灶及淋巴结转移灶中的表达和意义。方法采用免疫组织化学方法检测CK19和MUC2在7例结直肠印戒细胞癌原发灶和25枚转移淋巴结中的表达。结果 CK19、MUC2在结直肠印戒细胞癌原发灶及转移淋巴结中均呈阳性表达。阳性信号主要位于肿瘤细胞核周胞浆;淋巴结内固有细胞未见阳性表达。结论 CK19和MUC2的联合检测有助于结直肠印戒细胞癌的诊断。 Objective To investigate the expression and significance of CK19 and MUC2 in the primary tumor and lymph node metastasis of signet ring cell carcinoma of colorectum. Methods The expression of CK19 and MUC2 in seven primary colorectal signet-ring cell carcinomas and 25 metastatic lymph nodes were detected by immunohistochemistry. Results The positive expression of CK19 and MUC2 in primary tumor and metastatic lymph node of signet ring cell carcinoma of colorectal cancer were all positive. Positive signals were mainly located in the cytoplasm of the nucleus of the tumor cells; no positive cells were found in the lymph nodes. Conclusion The combined detection of CK19 and MUC2 contributes to the diagnosis of colorectal signet-ring cell carcinoma.