吡啶啉(PYD)和脱氧吡啶啉(DPD)是在骨胶原中发现的两种重要交联物.通称为吡啶鎓交联物.胶原基质降解时可随骨吸收作用释入血液.正常从尿中排出.因不存在于正常皮肤.筋膜及韧带的胶原中,故相对地具有骨胶原特异性.最近有些报告指出.测定尿吡啶鎓交联物能准确反映由疾病引起的骨代谢增强患者的骨周转状况.但几乎没有关于癌患者尿吡啶鎓交联物浓度方面的资料.本文作者对 Pyridinoline (PYD) and deoxypyridinoline (DPD) are two important cross-links found in collagen. They are known as pyridinium cross-links. When collagen matrix degrades, it can be released into the blood with bone absorption. Normal from urine Middle excretion. Because it does not exist in normal skin, fascia and ligament collagen, it is relatively specific collagen. Recently, some reports pointed out that the determination of urinary pyridinium cross-linked compound can accurately reflect the disease-induced bone metabolism in patients with increased The status of bone turnover. However, there is almost no information on the concentration of urinary pyridinium cations in cancer patients.