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[目的]分析mi R-196a-2基因多态位点rs11614913与乳腺癌易感性的关系。[方法]检索外文数据库Pubmed、Science Direct和中文数据库CNKI、万方,收集截止到2016年5月31日发表的关于mi R-196a-2基因多态位点rs11614913与乳腺癌易感关系的病例对照研究,按纳入与排除标准筛选文献,利用Meta分析的方法对各研究数据进行统计学处理及异质性检验,评估发表偏倚并进行敏感性分析。[结果]共纳入15篇研究mi R-196a-2基因多态位点rs11614913与乳腺癌易感关系的文献,包括6362例病例和7392例对照,结果显示:等位基因模型(T vs C)、隐形模型(TT vs CC+CT)和相加模型(TT vs CC)与降低乳腺癌发病风险相关,差异均有统计学意义(OR=0.89,95%CI:0.81~0.99;OR=0.83,95%CI:0.72~0.96;OR=0.79,95%CI:0.65~0.97)。按种族进行亚组分析后发现,在亚洲人群中,等位基因模型(T vs C)、显性模型(TT+CT vs CC)、隐形模型(TT vs CC+CT)和相加模型(TT vs CC)也与降低乳腺癌发病风险相关(OR=0.85,95%CI:0.75~0.95;OR=0.83,95%CI:0.70~0.99;OR=0.78,95%CI:0.67~0.91;OR=0.72,95%CI:0.57~0.91),其余模型均不能认为与乳腺癌的易感性相关。高加索人群的各遗传模型均与乳腺癌的发病风险无显著相关性。[结论]mi R-196a-2基因多态位点rs11614913的T等位基因和TT基因型可能与降低乳腺癌的发病风险相关。
[Objective] To analyze the relationship between rs11614913 polymorphism of mi R-196a-2 gene and breast cancer susceptibility. [Methods] We searched Pubmed, Science Direct and Chinese database CNKI and Wanfang to collect the cases of susceptibility to breast cancer in rs11614913 of mi R-196a-2 gene as of May 31, 2016 Controlled studies, screened the literature according to inclusion and exclusion criteria, used Meta-analysis to analyze the data of each study and test the heterogeneity, evaluated publication bias and conducted sensitivity analysis. [Results] A total of 15 articles were included in the literature, including 6362 cases and 7392 controls, on the relationship between rs11614913 polymorphism of mi R-196a-2 gene and susceptibility to breast cancer. The results showed that allele model (T vs C) (OR = 0.89, 95% CI: 0.81 ~ 0.99; OR = 0.83, P <0.05). The correlation between TT vs CC + CT and TT vs CC was significantly correlated with the risk of breast cancer (OR = 95% CI: 0.72 to 0.96; OR = 0.79, 95% CI: 0.65 to 0.97). A subgroup analysis by race found that in the Asian population, allele (TT vs CC), TT + CT vs CC, TT vs CC + CT and TT vs CC) were also associated with a lower risk of breast cancer (OR = 0.85, 95% CI: 0.75-0.95; OR = 0.83, 95% CI: 0.70-0.99; OR = 0.78, 95% CI: 0.67-0.91; OR = 0.72, 95% CI: 0.57-0.91), the other models can not be considered associated with the susceptibility to breast cancer. There was no significant correlation between the genetic models of Caucasians and the risk of breast cancer. [Conclusion] The T allele and TT genotype of rs11614913 in mi R-196a-2 gene polymorphism may be associated with the decreased risk of breast cancer.