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目的:探讨家族性食管癌组织中脆性组氨酸三联体基因(FHIT)和p53蛋白的表达。方法:采用免疫组织化学ABC法对74例河南省林州市食管癌患者(其中33例家族性食管癌,41例非家族性食管癌)手术切除标本癌及癌旁正常组织中FHIT及p53蛋白进行检测。结果:食管癌组织中FHIT蛋白异常表达率(39%,29/74)高于癌旁正常组织(3%,1/31),家族性食管癌组织中FHIT蛋白异常表达率(56%,18/33)高于非家族性食管癌组织(27%,11/41)(P均<0.05)。家族与非家族性食管癌组织p53蛋白阳性表达率差异无统计学意义(P>0.05)。结论:FHIT异常表达可能与食管癌家族高易感性密切相关;p53可能与其他易感因素协同作用,影响食管癌的发生。
Objective: To investigate the expression of FHIT and p53 in familial esophageal cancer tissues. Methods: Immunohistochemical ABC method was used to detect the expression of FHIT and p53 protein in 74 cases of esophageal cancer patients (33 cases of familial esophageal cancer and 41 cases of non-familial esophageal cancer) in Linzhou City, Henan Province. Test. Results: The abnormal expression of FHIT protein in ESCC (39%, 29/74) was higher than that in adjacent normal tissues (3%, 1/31), but not in familial esophageal carcinoma (56%, 18% / 33) than in non-familial esophageal cancer (27%, 11/41) (all P <0.05). There was no significant difference in the positive expression rates of p53 between familial and non-familial esophageal cancer (P> 0.05). Conclusion: The abnormal expression of FHIT may be closely related to the high susceptibility of esophageal cancer families. P53 may have synergistic effect with other susceptible factors and affect the occurrence of esophageal cancer.