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目的通过研究复发胶质瘤与初发胶质瘤肿瘤组织中细胞增殖核抗原KI-67表达水平的变化,了解胶质瘤复发后肿瘤的侵袭性的变化规律。方法回顾性分析免疫组化发检测的20例复发胶质瘤患者的首次手术及复发后再次手术的胶质瘤组织中KI-67表达水平,自身前后配对设计t检验;两次手术间隔时间与KI-67之间相关性以Pearson相关分析。结果复发胶质瘤肿瘤组织中KI-67较首次手术肿瘤组织的明显增加,差异具有统计学意义(P<0.05),两次手术间隔时间与KI-67变化幅度无明确相关性(P>0.05)。结论本研究表明:复发胶质瘤的侵袭性较初发胶质瘤明显增高且增高的幅度不受两次手术间隔时间影响。
Objective To study the expression of KI-67 in recurrent gliomas and primary gliomas and to find out the variation of tumor invasiveness after glioma recurrence. Methods The expression of KI-67 in glioma tissues of 20 patients with recurrent glioma detected by immunohistochemistry and retrospectively before and after operation were retrospectively analyzed. T-test was used to compare the two operation time and The correlation between KI-67 was analyzed by Pearson correlation. Results The KI-67 in recurrent glioma was significantly higher than that in the first operation (P <0.05). There was no significant correlation between the interval of two operations and the change of KI-67 (P> 0.05 ). Conclusions This study shows that the aggressiveness of recurrent glioma is significantly higher than that of primary glioma and the amplitude of increase is not affected by the two surgical intervals.