慢性 B 淋巴细胞白血病(B-CLL)患者的 B 和 T 淋巴细胞,其功能和细胞表型都有异常;患者有 E 玫瑰花结阳性细胞介导的自然杀伤细胞和 ADCC 活性缺乏。由于 NK 细胞参与对肿瘤的监视、杀伤以及正常造血讽控和防止病毒感染,因此,患者 NK 活性缺乏可能对该病的发展有一定的作用。作者检测了患者外周血单个核细胞、T 细胞和非T 细胞的 NK 活性。结果 NK 活性均较对照组明显降低,E 玫瑰花结阳性细胞 NK 活性缺乏尤其显著(P B and T lymphocytes from patients with chronic B-cell lymphocytic leukemia (B-CLL) have abnormalities in both function and cell phenotype; patients with E-rosette positive cells are deficient in natural killer cells and ADCC activity. Because NK cells are involved in tumor surveillance, killing and normal hematopoietic satiation and prevention of viral infection, the lack of NK activity in patients may have some effect on the development of the disease. The authors tested the NK activity of peripheral blood mononuclear cells, T-cells and non-T-cells in patients. Results NK activity was significantly lower than the control group, E rosette positive cells lack of NK activity was particularly significant (P