论文部分内容阅读
目的观察慢性肾功能不全(CRF)非透析患者中代谢综合征(MS)的发生率及其特点。方法收集2009-01-2010-01在我院肾内科住院的CRF非透析患者298例(非透析CRF组,男111例,女187例,年龄30~62岁),分为糖尿病肾病(n=30)与非糖尿病肾病组(n=268);同时在我院征募年龄、性别匹配的肾功能正常的健康体检者300人作为对照组。每例患者均进行腰围、血压、空腹血糖、血脂、血肝功能、肾功能、电解质24 h尿白蛋白及眼底检查等,采用国际糖尿病联盟的定义诊断MS。比较各组患者MS的发生率。结果非透析CRF组MS发生率明显高于对照组(21.8%比11.3%)。与对照组相比,非透析CRF组MS患者血压升高发生率(93.0%比35.0%)、血尿酸升高发生率(87.6%比20.7%)及高三酰甘油发生率(40.6%比25.7%)均明显增高(均P<0.01)。与非糖尿病肾病组的MS患者比较,糖尿病肾病组的MS患者腰围超标发生率(66.7%比25.4%)及空腹血糖升高发生率(100%比16.0%)均明显升高(均P<0.01)。结论慢性肾功能不全非透析患者MS及高尿酸发生率明显增高。
Objective To investigate the incidence and characteristics of metabolic syndrome (MS) in non-dialysis patients with chronic renal failure (CRF). Methods A total of 298 CRF non-dialysis patients (non-dialysis CRF group, 111 males and 187 females, aged 30-62 years) hospitalized in our department of Nephrology from January 2009 to October 2010 were enrolled and divided into diabetic nephropathy (n = 30) and non-diabetic nephropathy group (n = 268). At the same time, 300 healthy subjects with normal renal function and gender matched age were enrolled in our hospital as the control group. The waist circumference, blood pressure, fasting blood glucose, blood lipids, blood liver function, renal function, electrolytes 24 h urinary albumin and fundus examination were performed in each patient. MS was diagnosed by the definition of International Diabetes Federation. The incidence of MS in each group was compared. Results The incidence of MS in non-dialysis CRF group was significantly higher than that in control group (21.8% vs. 11.3%). Compared with the control group, the incidence of elevated blood pressure (93.0% vs. 35.0%), elevated serum uric acid (87.6% vs. 20.7%), and triglyceride (40.6% vs. 25.7% ) Were significantly higher (all P <0.01). Compared with patients with non-diabetic nephropathy, MS patients with diabetic nephropathy had significantly higher waist circumference (66.7% vs 25.4%) and higher fasting glucose (100% vs 16.0%) (all P <0.01) ). Conclusion The incidence of MS and hyperuricemia in non-dialysis patients with chronic renal failure is significantly higher.