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本文对甲型肝炎病毒L－A－1疫苗珠制备的多批减毒活疫苗放置不同温度、不同时间及反复冻融后的疫苗病毒的稳定性进行研究。结果表明，疫苗置－20℃16个月、4～8℃3个月，室温1周，35℃1天，疫苗清度仍达到≥6.5LogTCID50／ml的合格滴度。疫苗置室温3、5天后冻存一周，再放置室温3天，冻存一个月，其病毒滴度无明显改变，表明此疫苗稳定性良好，可耐受一定范围高温。
In this paper, we studied the stability of multiple attenuated live attenuated vaccines prepared at different temperatures, different times and repeated freezing and thawing of the vaccine virus prepared from hepatitis A virus L-A-1 vaccine beads. The results showed that the vaccines reached the qualified titer of≥6.5LogTCID50 / ml for 16 months at -20 ℃, 3 months at 4 ~ 8 ℃, 1 week at room temperature and 1 day at 35 ℃. The vaccine was stored at room temperature for 3,5 days, stored for one week, then stored at room temperature for 3 days, frozen for one month, the virus titer did not change significantly, indicating that the vaccine has good stability and can tolerate a range of high temperatures.