牙龈卟啉单胞菌(Porphyromonas gingivalis)是证据充分的重要的牙周致病菌之一,参与牙周炎的发生、发展及牙周组织的破坏过程。以往研究表明,牙周感染与全身健康及系统疾病均有着密切关系。P.gingivalis感染多种宿主细胞后,通过干扰相关信号传导及蛋白表达,对宿主细胞凋亡进行调控。现就P.gingivalis感染宿主细胞后对其凋亡调控研究进展做一综述。 Porphyromonas gingivalis is one of the most important periodontal pathogens that are involved in the occurrence and development of periodontitis and the process of periodontal tissue destruction. Previous studies have shown that periodontal infection and systemic health and systemic diseases are closely related. After P. gingivalis infect a variety of host cells, host cell apoptosis is regulated by interfering with related signal transduction and protein expression. The progress on the regulation of apoptosis of P.gingivalis infected host cells is reviewed.