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所收集的64株金葡菌中耐甲氧西林菌株(MRSA)已达50％,去甲基万古霉素和环丙沙星对MRSA和MSSA有较好抗菌活性;头孢唑林对MSSA呈高活性,而对MRSA敏感性明显低于MSSA;培氟沙星和诺氟沙星体外抗金葡菌活性较环丙沙星差;青霉素,红霉素对MRSA几乎无效。 观察了35例用培氟沙星和诺氟沙星治疗的金葡菌所致皮肤软组织感染(11例)和泌尿系感染(24例)的临床疗效。前者痊愈9/11例,有效100％,泌尿系感染MRSA12例痊愈1例、有效8例,MSSA组12例痊愈7例,有效100％。
The methicillin-resistant strains (MRSA) of the 64 Staphylococcus aureus strains collected had reached 50%, and methamcosin and ciprofloxacin showed good antibacterial activity against MRSA and MSSA. Cefazolin showed high MSSA While the sensitivity to MRSA was significantly lower than that of MSSA. Pefloxacin and norfloxacin showed less antimicrobial activity than ciprofloxacin in vitro. Penicillin and erythromycin were almost ineffective against MRSA. The clinical efficacy of 35 cases of skin and soft tissue infections (11 cases) and urinary tract infections (24 cases) caused by Staphylococcus aureus treated with pefloxacin and norfloxacin was observed. The former recovered 9/11 cases, effective 100%, urinary tract infection MRSA 12 cases recovered in 1 case, effective in 8 cases, MSSA group of 12 patients cured in 7 cases, 100% effective.