由于微生物学家W S Tillett发现β-溶血性链球菌可合成一种能激活人体纤溶系统的物质(链激酶),纤维蛋白溶酶原-纤维蛋白溶酶系统才有可能应用于临床治疗。此后将近20年,又发现人尿中含有一种具有类似活性的物质(尿激酶)。虽然1960年以前对这些物质的生化学特性能引起纤维蛋白溶解,以及它们在静脉血栓栓 Since the microbiologist W S Tillett has found that β-hemolytic streptococcus synthesizes a substance that activates the human fibrinolytic system (streptokinase), the plasminogen-plasmin system has potential for clinical use. Nearly 20 years later, it was found that human urine contains a substance with similar activity (urokinase). Although the biochemical properties of these substances before 1960 can cause fibrinolysis, and their role in venous thromboembolism