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目的观察阿托伐他汀对非酒精性脂肪性肝病患者的疗效及对肝功能的影响。方法应用阿托伐他汀和复方益肝灵片为治疗组;单独应用益肝灵片为对照组,治疗12周,观察肝功能、血脂方面的变化。结果血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇均有不同程度的降低;高密度脂蛋白胆固醇有所升高,达到有效值,与对照组相比差异均有统计学意义(P<0.01);肝脏功能也有明显改善。结论小剂量阿托伐他汀治疗非酒精性脂肪性肝病疗效确切、安全,值得临床借鉴。
Objective To observe the effect of atorvastatin on nonalcoholic fatty liver disease and its effect on liver function. Methods Atorvastatin and Yigangan tablets were used as the treatment group. Yigangan tablets alone was used as the control group for 12 weeks. The changes of liver function and blood lipid were observed. Results Serum total cholesterol, triglyceride and low-density lipoprotein cholesterol decreased to some extent; high-density lipoprotein cholesterol increased to an effective value, compared with the control group, the difference was statistically significant (P <0.01 ); Liver function has also been significantly improved. Conclusion Low-dose atorvastatin treatment of non-alcoholic fatty liver disease is effective and safe, it is worth learning from.