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Wnt信号通路是调控细胞生长增殖的重要通路之一,其成分不恰当地激活与肿瘤的发生、发展有关,尤其与消化道肿瘤的发生、发展密切相关。本文对Wnt信号通路在食管癌、胃癌、肝细胞癌、结直肠癌等的发生、发展的作用作简要综述,以探究其各组分及相互作用机制,为消化道肿瘤的治疗提供应用前景。
Wnt signaling pathway is one of the important pathways regulating cell growth and proliferation. The inappropriate activation of Wnt signaling pathway is related to the occurrence and development of tumors, especially to the occurrence and development of digestive tract tumors. This article briefly reviews the role of Wnt signaling pathway in the occurrence and development of esophageal cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, etc. to explore its various components and interaction mechanisms, and to provide application prospects for the treatment of gastrointestinal cancer.