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目的:介绍临床常用抗真菌药物的药动学和药效学研究进展,旨在为临床合理用药提供相关依据。方法:查阅国内、外相关文献,进行系统的阅读复习,并进行综合分析。结果:真菌感染发病复杂,诊断困难,预后较差,但是抗真菌药物研发的不断进步,为临床医生用药提供了更多选择,真菌感染的治疗和预后将逐步得到改善。结论:临床常用抗真菌药物的药动学和药效学研究,对于临床合理用药具有重要的指导意义。
Objective: To introduce the research progress of pharmacokinetics and pharmacodynamics of commonly used antifungal drugs, and to provide relevant evidences for clinical rational drug use. Methods: Access to domestic and foreign literature, systematic reading review, and a comprehensive analysis. Results: The incidence of fungal infection is complicated, the diagnosis is difficult, and the prognosis is poor. However, the progress of antifungal drug research and development provides more choices for clinicians and the treatment and prognosis of fungal infection will be gradually improved. Conclusion: The study of pharmacokinetics and pharmacodynamics of commonly used antifungal drugs has important guiding significance for clinical rational use of drugs.