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目的:探讨急性时相反应蛋白(APRP)在2型糖尿病诊治中的意义。方法:对27例糖耐量受损的患者和66例2型糖尿病患者诊治过程中血中C-反应蛋白(CRP)、血清淀粉样蛋白A(SAA)、前白蛋白(PA)等急性时相反应蛋白进行检测。结果:2型糖尿病者血CRP、SAA明显高于对照组,且依照糖耐量受损(IGT)、无慢性合并症的2型糖尿病、合并慢性并发症的2型糖尿病的顺序显著增高;2型糖尿病者血PA明显低于对照组。相关分析表明:CRP与SAA之间呈正相关,CRP和SAA与空腹血糖(FPG)呈正相关,PA与CRP、SAA和FPG之间呈负相关。结论:CRP、SAA是监测2型糖尿病发病、严重程度及预后的又一类灵敏指标。
Objective: To investigate the significance of acute phase reaction protein (APRP) in the diagnosis and treatment of type 2 diabetes mellitus. Methods: The acute phase of C-reactive protein (CRP), serum amyloid A (SAA) and prealbumin (PA) in 27 patients with impaired glucose tolerance and 66 patients with type 2 diabetes mellitus The reaction protein is tested. Results: The blood levels of CRP and SAA in type 2 diabetic patients were significantly higher than those in control subjects. The type 2 diabetic patients with type 2 diabetes mellitus complicated with impaired glucose tolerance (IGT) Diabetic patients with blood PA was significantly lower than the control group. Correlation analysis showed that there was a positive correlation between CRP and SAA, CRP and SAA were positively correlated with fasting plasma glucose (FPG), PA was negatively correlated with CRP, SAA and FPG. Conclusion: CRP and SAA are another sensitive indicators to monitor the incidence, severity and prognosis of type 2 diabetes mellitus.