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脓毒症通常是继发于危重疾病和严重感染(脏器感染或组织感染)的临床综合症。有统计发现~([1]),全球每年严重脓毒症患者的发病率超过1800万例次,并且每年以1%-5%的速度增加,死亡率达到或超过了25%。近年来,虽然抗菌药物、器官支持技术及重症监护技术不断地发展和改进,然而,脓毒症的病死率并未得到明显降低。研究发现,在脓毒症的发病机制中,肠道损伤被认为是重要的中间病理环节,起着非常重要的作用。无论是应激状态下,肠道黏膜缺血缺氧或液体复苏再灌注损伤,还是脓毒症时,炎症介质、免疫
Sepsis is usually a clinical syndrome secondary to critical illnesses and serious infections (organ or tissue infections). It has been found that ~ ([1]), the annual global incidence of severe sepsis is more than 18 million cases, and the annual increase of 1% -5%, the mortality rate reached or exceeded 25%. In recent years, although the antibacterial drugs, organ support technology and intensive care technology continue to develop and improve, however, the mortality rate of sepsis has not been significantly reduced. The study found that in the pathogenesis of sepsis, intestinal damage is considered an important intermediate pathological link, plays a very important role. Whether under stress, intestinal mucosal ischemia and hypoxia or fluid resuscitation and reperfusion injury, or sepsis, the inflammatory mediators, immune