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目的探讨儿童过敏性紫癜肾损害的相关因素。方法对230例过敏性紫癜患儿肾损害的相关因素进行回顾性分析。结果紫癜性肾炎的发生率为38.70%(89/230),男女之比为2.18∶1(P<0.05)。皮肤紫癜反复在非肾损组占19.15%(27/141),而在肾损组占53.93%(48/89),两组比较差异有统计学意义(P<0.05)。皮肤紫癜伴有消化道症状的患儿以及生活在矿区的患儿肾损害的发生率明显高于单纯皮肤紫癜以及生活在城市者(P<0.05)。结论男性更易发生肾损害,皮肤紫癜反复或合并消化道症状或生活在矿区者肾脏更易受累及。
Objective To investigate the related factors of renal damage in children with Henoch-Schonlein purpura. Methods Retrospective analysis of the related factors of renal damage in 230 children with Henoch-Schonlein purpura. Results The incidence of purpura nephritis was 38.70% (89/230). The ratio of male to female was 2.18:1 (P <0.05). Purpura repeatedly accounted for 19.15% (27/141) in non-renal injury group and 53.93% (48/89) in renal injury group, the difference between the two groups was statistically significant (P <0.05). The incidence of renal damage in children with purpura associated with gastrointestinal symptoms and children living in mining areas was significantly higher than that of pure purpura and those living in urban areas (P <0.05). Conclusion Men are more prone to kidney damage, skin purpura repeatedly or with gastrointestinal symptoms or living in the mining area of the kidney are more likely to be involved.