本文叙述二十个与放线菌素有关的化合物1,9-二(N-烷基-甲氨酰(或烷氧羰基)]-4,6-二取代基(H或CH_3)-2-氨基吩噁嗪酮-(3)的合成.企图从增加化合物的脂溶性,以观察其与抗肿瘤作用的关系.经初步生物试验发现,化合物III_a,IV_a,V_a和VI_a在浓度100微克/毫升时,对体外培养的Hela细胞有一定的抑制作用,但对小白鼠肉瘤180及肉瘤37和抗菌试验均无明显作用. Twenty ten compounds that are related to actinomycin are described herein as 1,9-bis (N-alkyl-carbamoyl (or alkoxycarbonyl)] -4,6-disubstituted (H or CH 3) Amino phenoxazone- (3) was synthesized in order to increase the lipophilicity of the compounds and to observe their relationship with anti-tumor effects.According to the preliminary bioassay, the compounds IIIa, IVa, Va and VIa were tested at the concentration of 100 μg / Hela cells cultured in vitro have certain inhibitory effect on mouse sarcoma 180 and sarcoma 37 and antibacterial test had no significant effect.