论文部分内容阅读
目的 探讨血浆蛋白Ｃ（ＰＣ）在缺血性脑血管病（ＩＣＶＤ）发生中的变化及其作用。方法 用放射免疫法和酶联免疫吸附法测定８０例缺血性脑血管病患者［短暂性脑缺血发作（ＴＩＡ）２２ 例，脑梗死（ＣＩ）５８例］和３６ 名正常对照者的血浆ＰＣ及假血友病因子（ｖＷＦ）活性水平。结果 ＴＩＡ组血浆ＰＣ水平较对照组降低（Ｐ＜ ０．０５），ＣＩ急性期组血浆ＰＣ降低明显，恢复期组有所回升，但均低于对照组水平（均Ｐ＜ ０．０５）；血浆ＰＣ水平与血浆ｖＷＦ活性水平成负相关。与梗死灶最大直径呈负相关。结论 ＩＣＶＤ早期即存在高凝状态，血浆ＰＣ参与了其发生过程，并可作为判断病情及预后的一项指标。
Objective To investigate the change and its role of plasma protein C (PC) in the pathogenesis of ischemic cerebrovascular disease (ICVD). Methods Totally 80 plasma samples from 80 patients with ischemic cerebrovascular disease [TIA (transient ischemic attack (TIA), 58 cerebral infarction (CI)] and 36 normal controls were measured by radioimmunoassay and enzyme-linked immunosorbent assay PC and von Willebrand factor (vWF) activity levels. Results The level of plasma PC in TIA group was lower than that in control group (P <0.05). The plasma PC level in acute phase of CI group was significantly lower than that in control group (P <0.05). Plasma PC levels were negatively correlated with plasma vWF activity levels. Negative correlation with the maximum diameter of infarction. Conclusions There is a hypercoagulable state in the early stage of ICVD. Plasma PC participates in the process of ICVD and may be used as an index to judge the condition and prognosis.