Ugi-4CC四组份缩合反应是基于异腈的MCR＇s(多组份缩合反应)之中一类,它以异腈、羧酸、醛、胺为原料,可经一罐反应缩合生成由四种起始物共同组成的产物.此反应充分利用异腈的特性,通过使用不同的反应物,可用于合成不同结构骨架的系列化合物.本文合成了两种异腈,并进行了一系列Ugi反应以改进反应条件.“,”Ugi-4CC(four-component condensation) reaction is one of isonitrile-based MCR＇s(multi-component reactions), which is started with an amine, an aldehyde, a carboxylic acid and an isocyanide, after one-potreaction to produce a compound composed of the whole four starting materials. The reaction makes full use of thespecialty of isonitrile and can be used to build a series of compounds with different structural skeletons by usingdiverse inputs. In our work, two kinds of isonitriles were synthesized and a parallel synthesis of an α-acylaminoamide library was performed to modify the Ugi reaction conditions.