论文部分内容阅读
目的:探讨富氢盐水对高压电烧伤大鼠微循环内红细胞流速及组织病理损伤的影响。方法:80只大鼠随机分为四组,分别为烧伤组、治疗组、对照组和阳性对照组,治疗组烧伤后给予富氢盐水治疗,阳性对照组给予罂粟碱溶液治疗。每组分成三个亚组用于血气分析,肺组织形态学观察和红细胞流动速度检测。结果:治疗组和阳性对照组大鼠肺组织湿干重比均显著低于烧伤组(P<0.05),治疗组和阳性对照组大鼠肺组织湿干重比差异不显著(t=0.585,P>0.05)。治疗组和阳性对照组大鼠生存时间均显著高于烧伤组(P<0.05),治疗组和阳性对照组大鼠生存时间差异不显著(t=0.448,P>0.05)。治疗组和阳性对照组氧分压均显著高于烧伤组(P<0.05);治疗组和阳性对照组氧分压差异不显著(t=0.424,P>0.05)。治疗组和阳性对照组二氧化碳分压均显著低于烧伤组(P<0.05);治疗组和阳性对照组二氧化碳分压差异不显著(t=1.285,P>0.05)。治疗组和阳性对照组大鼠红细胞流动速度分压均显著高于烧伤组(P<0.05);治疗组和阳性对照组之间大鼠红细胞流动速度差异不显著(P>0.05)。结论:富氢盐水能够促进烧伤大鼠微循环内红细胞的流动,改善微循环,恢复受损肺组织,在高压电烧伤患者的治疗方面具有较好的应用前景。
Objective: To investigate the effect of hydrogen-enriched saline on erythrocyte flow rate and histopathological damage in microcirculation of high-voltage electric burn rats. Methods: Eighty rats were randomly divided into four groups: burn group, treatment group, control group and positive control group. The treatment group was treated with hydrogen-rich salt water after burn, while the positive control group was treated with papaverine solution. Each subgroup was divided into three subgroups for blood gas analysis, lung histomorphology, and red blood cell flow velocity. Results: The wet / dry weight ratio of the lungs in the treated group and the positive control group were significantly lower than those in the burn group (P <0.05), while the wet / dry weight ratio in the treated group and the positive control group was not significantly different (t = 0.585, P> 0.05). The survival time in the treatment group and the positive control group was significantly higher than that in the burn group (P <0.05). There was no significant difference in the survival time between the treatment group and the positive control group (t = 0.448, P> 0.05). Oxygen partial pressure in treatment group and positive control group was significantly higher than that in burn group (P <0.05). There was no significant difference in oxygen partial pressure between treatment group and positive control group (t = 0.424, P> 0.05). The partial pressure of carbon dioxide in the treatment group and the positive control group was significantly lower than that in the burn group (P <0.05). There was no significant difference in the partial pressures of carbon dioxide between the treatment group and the positive control group (t = 1.285, P> 0.05). The partial pressure of erythrocyte flow velocity in the treatment group and the positive control group was significantly higher than that in the burn group (P <0.05). There was no significant difference in the erythrocyte flow velocity between the treatment group and the positive control group (P> 0.05). CONCLUSION: Hydrogen-enriched saline can promote the flow of red blood cells in microcirculation, improve microcirculation and restore damaged lung tissue in burn rats, and has a good application prospect in the treatment of patients with high voltage electric burn.