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目的:探讨糖尿病患者的周围神经传导速度异常的发生率及其影响因素。方法:对经肌电图检测周围神经传导速度的205例糖尿病患者的临床资料进行回顾性分析,分析周围神经病变的发生率及与病程的关系,并将周围神经传导速度与患者的年龄、血压及空腹血糖、血脂、糖化血红蛋白水平,是否合并冠状动脉粥样硬化性心脏病等作多因素Logistic回归分析。结果:神经传导速度异常者138例(检出率67%),病程超过10年者与不足10年者的检出率分别为76%、60%,差异有统计学意义(P<0.05)。感觉神经病变的发生率(41%)明显高于运动神经病变(28%),下肢周围神经病变的发生率(49%)明显高于上肢周围神经病变(33%),差异均有统计学意义(P<0.01)。糖化血红蛋白和收缩压水平是周围神经病变的危险因素。结论:病程较长的糖尿病患者周围神经病变的发生率较高,高血糖状态和收缩压升高是糖尿病周围神经病变的危险因素。
Objective: To investigate the incidence of diabetic peripheral nerve conduction velocity and its influencing factors. Methods: The clinical data of 205 diabetic patients with peripheral nerve conduction velocity detected by electromyography were retrospectively analyzed. The incidence of peripheral neuropathy and its relationship with the course of disease were analyzed. The peripheral nerve conduction velocity was correlated with the age, And fasting blood glucose, blood lipids, glycosylated hemoglobin, whether or not coronary heart disease complicated by multiple factor Logistic regression analysis. Results: There were 138 cases (67%) with abnormal nerve conduction velocity and 76% and 60% respectively in those with more than 10 years and less than 10 years of disease duration. The difference was statistically significant (P <0.05). The incidence of sensory neuropathy (41%) was significantly higher than that of motor neuropathy (28%), and the incidence of peripheral neuropathy (49%) was significantly higher than that of peripheral neuropathy (33%) in upper extremities. The differences were statistically significant (P <0.01). HbA1c and systolic blood pressure are risk factors for peripheral neuropathy. Conclusion: Diabetic patients with longer course of disease have a higher incidence of peripheral neuropathy, hyperglycemia and elevated systolic blood pressure are risk factors of diabetic peripheral neuropathy.