目的与方法 :本文采用Ames试验及活体小鼠骨髓嗜多染红细胞微核试验方法 ,对香菇多糖胶囊进行抗突变试验 ,结果 :香菇多糖胶囊各剂量组在加与不加S9的条件下 ,均能抑制由 2 -氨基芴等阳性物引起的TA98、TA10 0回变菌落数的增加 ;抑制由环磷酰胺引起的小鼠微核率的增加 ,抑制率在 45 .32 % - 6 4.72 %。结论 :香菇多糖胶囊具有一定的抗突变作用 Objectives and methods: In this paper, Ames test and micronucleus test of bone marrow polychromatic erythrocytes in living mice were used to test the anti-mutagenicity of lentinan capsules. Results: All doses of lentinan capsules were added with or without S9. It can inhibit the increase of colony counts of TA98 and TA100 induced by positive substances such as 2-aminoindole and inhibited the increase of micronucleus rate induced by cyclophosphamide. The inhibition rate was 45.32% - 64.72%. Conclusion : Lentinan capsule has certain antimutagenic effect