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目的:评价纯尿促卵泡素(FSH)治疗特发性少弱精子症的疗效。方法:从2006年6月—2009年6月,对120例男性不育患者中的少弱精子症人群,随机2组治疗:对照组(60例)采用传统的甘草锌颗粒1.5g,bid,维生素E胶丸100mg,bid;治疗组(60例)在对照组治疗药物的基础上加用纯FSH75IU,每3d一次,肌肉注射1~3个月,疗程3个月。结果:对照组58例,治疗组56例完成随访且进行复查。治疗组血睾酮提高,精液检查参数改善,配偶妊娠率均明显高于对照组,差异有显著性意义(P<0.01)。结论:纯FSH治疗男性特发性少弱精子症可改善患者的精液量,精子密度,活动力及精子活率,从而提高患者配偶的妊娠率。
Objective: To evaluate the efficacy of pure follicle stimulating hormone (FSH) in the treatment of idiopathic oligospermia. Methods: From June 2006 to June 2009, 120 oligozoospermia patients with male infertility were randomized into two groups: the control group (60 cases) was treated with traditional licorice zinc granules 1.5g, bid, Vitamin E capsules 100mg, bid; treatment group (60 cases) in the control group based on the treatment of drugs plus pure FSH75IU, once every 3d, intramuscular injection of 1 to 3 months for 3 months. Results: 58 cases in the control group and 56 cases in the treatment group were followed up and were reviewed. Serum testosterone was increased in the treatment group, semen parameters were improved, and pregnancy rate of spouses was significantly higher than that of the control group (P <0.01). Conclusion: Treatment of idiopathic oligoasthenospermia with pure FSH can improve the sperm volume, sperm density, motility and sperm motility of the patients, so as to improve the pregnancy rate of the spouses.