AIM To investigate correlation of perinatal risk factors in newborns with gastrointestinal perforation(GIP).METHODS Single-center retrospective cohort study was conducted between January 1990 and December 2012. Medical records on all newborns with GIP were reviewed(n=35). Surgical records and histopathologic examination of all perforated intestine samples were also reviewed.RESULTS The most common cause of GIP was necrotizing enterocolitis(51.4%). The most common site of perforation was large intestine. Mortality rate was 31%. Infants with GIP more frequently had very low birth weight(<1500 g),especially birth weight below 10~(th)percentile according to gestational age. Ponderal index was not differing between infants with GIP and control subjects.In infants with GIP anemia was more frequently found than in control group.CONCLUSION GIP in newborns is mostly disease of infants with birth weight below 10~(th)percentile according to gestationa age. GIP occurs more often in infants with anemia. AIM To investigate correlation of perinatal risk factors in newborns with gastrointestinal perforation (GIP). METHODS Single-center retrospective cohort study was conducted between January 1990 and December 2012. Medical records on all newborns with GIP were reviewed (n = 35). Surgical records and histopathologic examination of all perforated intestine samples were also reviewed .RESULTS The most common cause of GIP was necrotizing enterocolitis (51.4%). The most common site of perforation was large intestine. Mortality rate was 31%. Infants with GIP more frequently had very low birth weight (<1500 g), especially birth weight below 10 ~ (th) percentile according to gestational age. Ponderal index was not differ between infants with GIP and control subjects. In infants with GIP anemia was more frequently found than in control group .CONCLUSION GIP in newborns is mostly disease of infants with birth weight below 10 ~ (th) percentile according to gestationa age. GIP occurs more often in infants with an emia.