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目的分析血清胱抑素C在高血压肾病检测中的价值。方法随机选择2014年2月—2015年1月本院诊治的高血压肾病患者78例作为研究组,健康查体的健康者60例为对照组,同时检测研究组肌酐、尿素及血清胱抑素C水平,计量资料以±s表示,采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果研究组的肌酐、尿素、血清胱抑素C水平[(141.08±34.85)μmol/L、(9.55±4.15)mmol/L、(1.38±0.4)mg/L]较对照组[(42.26±11.98)μmol/L、(6.32±2.88)mmol/L、(0.68±0.24)mg/L]高,两组对比差异均有统计学意义(均P<0.05)。研究组的血清胱抑素C的阳性检出率(96.15%)高于其余各项检测指标(62.82%、61.53%),对比差异有统计学意义(P<0.05)。结论与肌酐、尿素相比,血清胱抑素C是一个更准确、更敏感诊断早期高血压肾病的指标。
Objective To analyze the value of serum cystatin C in the detection of hypertensive nephropathy. Methods Totally 78 patients with hypertensive nephropathy diagnosed and treated in our hospital from February 2014 to January 2015 were selected as research group and 60 healthy controls were selected as control group. Creatinine, urea and serum cystatin C level, measurement data to ± s said, using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results Compared with the control group [(42.26 ± 11.98), creatinine, urea and serum cystatin C levels in the study group [(141.08 ± 34.85) μmol / L, (9.55 ± 4.15) mmol / L, ) (μmol / L, (6.32 ± 2.88) mmol / L, (0.68 ± 0.24) mg / L] respectively. There was significant difference between the two groups (all P <0.05). The positive detection rate of serum cystatin C (96.15%) in the study group was higher than the other detection indexes (62.82%, 61.53%), the difference was statistically significant (P <0.05). Conclusions Compared with creatinine and urea, serum cystatin C is a more accurate and sensitive indicator of early hypertensive nephropathy.