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头孢菌素类抗生素是一族广谱半合成抗生素,其母核为7—氨基头孢烷酸(7—ACA),头孢菌素类因杀菌力强,耐青霉素酶,抗菌潜广,临床疗效高,毒性低,过敏反应较青霉素类少等优点,目前在临床抗感染中的应用已十分广泛。笔者随机抽查了1989年度本院内科住院病历1000份,使用头孢菌素类者共占64％(其中头孢唑啉钠占63％,其它头孢菌素占1％);头孢菌素类所致变态反应在全都使用头孢菌素类的病人中约占1.1％。根据本院的临床用药情况,笔者又走访调查了30家省、市级医院,结果头孢菌素类的临床使用率约在30％以上,其变态反应发生率为1％左右,而且曾发现严重过敏性休克病例。
Cephalosporins antibiotics is a family of broad-spectrum semi-synthetic antibiotics, its mother nucleus 7-amino cephalosporanic acid (7-ACA), cephalosporins due to strong bactericidal, penicillinase-resistant, antibacterial potential wide, high clinical efficacy, Low toxicity, less allergic reactions than penicillin and other advantages, the current clinical anti-infection has been widely used. The author randomly selected the 1989 medical hospital inpatient medical records of 1000, the use of cephalosporins accounted for a total of 64% (of which cefazolin sodium accounted for 63%, other cephalosporins accounted for 1%); cephalosporins metamorphosis The response accounted for about 1.1% of all patients who used cephalosporins. According to the hospital’s clinical drug use, the author also visited 30 provincial and municipal hospitals, the results of the clinical use of cephalosporins about 30% or more, the incidence of allergy was about 1%, and had found serious Anaphylactic shock cases.