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为了探讨乙型肝炎病毒感染和原发性细胞肝癌发生之间的关系.对10例病理组织学确诊为原发性肝细胞癌患者外科切除的肝癌和癌旁肝组织,用酶抗酶可溶性复合物(PAP)法定位肝细胞中乙型肝炎病毒抗原。5例患者肝细胞中检出HBsAg。HBsAg 在肝细胞中呈弥漫型分布的有3例;另2例以包含体型为主.此5例患者血清 HBsAg 均阳性。另5例患者肝细胞中未检出 HBV 抗原。病理组织学检查结果表明,肝细胞有 HBV 标志的5例癌旁肝组织中有4例呈现肝炎后肝硬化组织特点,面肝细胞 HBV 标志阴性的5例癌旁肝组织中无1例有肝炎后肝硬化组织学特征。上述结果提示:HBV 慢性感染导致肝组织慢性损害可能是诱发肝细胞癌的主要原因。
In order to investigate the relationship between hepatitis B virus infection and primary hepatocellular carcinoma (HCC), 10 cases of histopathologically diagnosed hepatocellular carcinoma and paracancerous liver tissue from patients with primary hepatocellular carcinoma were treated with enzyme-reactive enzyme soluble complexes. The PAP method localizes hepatitis B virus antigen in liver cells. HBsAg was detected in liver cells in 5 patients. There were 3 cases of diffuse distribution of HBsAg in hepatocytes, and the other 2 cases included body size. The serum HBsAg was positive in all 5 cases. In the other 5 patients, no HBV antigen was detected in the liver cells. Histopathological examination showed that 4 out of 5 paracancerous liver tissues with HBV markers in hepatocytes exhibited characteristics of posthepatitic cirrhosis, and none of the 5 hepatocellular carcinoma tissues with negative hepatocellular HBV markers had hepatitis. Histological features of post-cirrhosis. The above results suggest that chronic infection of the liver caused by chronic HBV infection may be the main cause of hepatocellular carcinoma.