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目的探讨辛伐他汀对血脂正常的稳定型心绞痛患者心肌缺血的影响。方法将58例血脂正常的稳定型心绞痛患者随机分为辛伐他汀组(治疗组)和对照组,对照组给予常规治疗,治疗组在常规治疗的基础上口服辛伐他汀片20 mg,每晚1次,并于治疗前、治疗后6个月分别做24 h动态心电图、心电图运动试验,检测心肌缺血总负荷(TIB)及运动诱发的心肌缺血,并记录缺血相关事件。结果治疗后6个月治疗组TIB低于对照组(P<0.05)。治疗组运动耐量增加,由运动诱发的心肌缺血低于对照组(P<0.05)。治疗组的缺血相关事件明显少于对照组(P<0.05)。结论辛伐他汀对血脂正常的稳定型心绞痛患者可明显改善心肌缺血,并能减少运动诱发的心肌缺血以及缺血相关事件的发生。
Objective To investigate the effect of simvastatin on myocardial ischemia in patients with stable serum lipids. Methods 58 patients with stable angina pectoris were randomly divided into simvastatin group (treatment group) and control group. The control group was given routine treatment. The treatment group received 20 mg simvastatin tablets on a regular basis, 1, and 24 h Holter, electrocardiogram exercise test, total myocardial ischemic load (TIB) and exercise-induced myocardial ischemia were performed before treatment and 6 months after treatment, and ischemic related events were recorded. Results At 6 months after treatment, the TIB in the treatment group was lower than that in the control group (P <0.05). The exercise tolerance of the treatment group increased, and the myocardial ischemia induced by exercise was lower than that of the control group (P <0.05). The ischemia-related events in the treatment group were significantly less than those in the control group (P <0.05). Conclusion Simvastatin can significantly improve myocardial ischemia in patients with stable serum lipids and reduce the occurrence of exercise-induced myocardial ischemia and ischemia-related events.