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目的探讨慢性心力衰竭(CHF)患者红细胞分布宽度(RDW)及血清总胆红素(TBi L)、尿酸(UA)水平与心功能分级的关系。方法选取2012年5月—2015年5月清河县中心医院心血管内科收治的CHF患者280例,按美国纽约心脏病协会(NYHA)心功能分级将患者分为心功能Ⅱ级组89例,心功能Ⅲ级组124例,心功能Ⅳ级组67例;另选取同期心功能正常的患者59例作为对照组。观察4组患者一般资料、RDW、血清TBi L、UA水平。结果 4组患者年龄、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平比较,差异无统计学意义(P>0.05);心功能Ⅱ级、Ⅲ级、Ⅳ级组患者男性、高血压、糖尿病、吸烟比例、丙氨酸氨基转移酶(AST)水平高于对照组,差异有统计学意义(P<0.05)。心功能Ⅱ级、Ⅲ级、Ⅳ级组患者RDW、血清TBi L、UA水平高于对照组,差异有统计学意义(P<0.05);心功能Ⅲ级组、Ⅳ级组患者RDW、血清TBi L、UA水平高于心功能Ⅱ级组,差异有统计学意义(P<0.05)。结论 RDW、血清TBi L、UA水平与心功能分级有关,可作为评估CHF患者病情严重程度、预后的指标。
Objective To investigate the relationship between RDW, TBiL, UA and cardiac function in patients with chronic heart failure (CHF). Methods Two hundred and eighty-two CHF patients admitted to Department of Cardiology, Qinghe Central Hospital from May 2012 to May 2015 were enrolled. According to the New York Heart Association (NYHA) cardiac function classification, 89 patients were divided into two groups: heart function Ⅱ group (n = 89) There were 124 patients with grade Ⅲ function and 67 patients with grade Ⅳ function. Another 59 patients with normal cardiac function were selected as the control group. General data, RDW, serum TBi L and UA levels were observed in 4 groups. Results There were no significant differences in age, triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) between the 4 groups (P> 0.05) , Hypertension, diabetes, smoking and alanine aminotransferase (AST) were significantly higher than those in the control group (P <0.05). The levels of RDW, serum TBi L and UA in patients with grade Ⅱ, Ⅲ and Ⅳ cardiac function were significantly higher than those in the control group (P <0.05). The levels of RDW, serum TBi L, UA levels were higher than those of heart function Ⅱ group, the difference was statistically significant (P <0.05). Conclusions The levels of RDW, serum TBiL and UA are related to the grading of cardiac function, which can be used as an index to evaluate the severity and prognosis of CHF patients.