目的:总结保留脾脏的胰体尾切除术经验,探讨其可行性与安全性。方法:回顾性分析我院院2006年9月至2015年7月行保留脾脏的胰体尾切除术18例病人的临床资料。结果:18例病人中,无功能胰岛细胞瘤2例、囊腺瘤11例、胰岛素瘤2例、胰尾淋巴管瘤3例,均成功完成保留脾脏的胰体尾切除术。无围手术期死亡。术后发生胰瘘5例,经非手术治疗2~3周痊愈。结论:对于胰体尾部良性病变者,不适合行摘除术时应首先选择保留脾脏的胰体尾切除术,安全可行。 OBJECTIVE: To summarize the experience of preserving spleen and pancreatectomy and to explore its feasibility and safety. Methods: A retrospective analysis of our hospital from September 2006 to July 2015 to retain spleen pancreatic tail resection in 18 patients with clinical data. Results: Of the 18 patients, 2 cases of non-functional islet cell tumor, 11 cases of cystadenoma, 2 cases of insulinoma and 3 cases of lymphangioma of pancreas were successfully completed the pancreatic body tail resection to retain the spleen. No perioperative deaths. 5 cases of pancreatic fistula occurred after surgery, non-surgical treatment of 2 to 3 weeks recovered. Conclusion: For patients with benign lesions of the pancreatic body and tail, it is safe and feasible to choose the pancreatic body tail resection which retains the spleen when not suitable for extirpation.