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目的 :探讨葛根素联用极化液对急性心肌梗死 (AMI)患者治疗前后 QT离散度 (QTd)、校正 QT间期离散度 (QTcd)的影响 ,以及严重室性心律失常的发生率。方法 :采用随机单盲方法 ,将 5 5例 AMI患者分为治疗组和对照组 ,测定 2组患者用药前后的 QTd和 QTcd,及严重室性心律失常的发生率。结果 :2组治疗前后QTd和 QTcd均显著降低 (P均 <0 .0 1)。治疗组严重室性心律失常的发生率为 10 .3% (3/2 9) ,显著低于对照组 34 .6 % (9/2 6 ,P<0 .0 5 )。结论 :葛根素与极化液联用能降低 AMI患者 QTd和严重室性心律失常的发生率。
Objective: To investigate the influence of puerarin combined with polarizer on QTd, QTcd in patients with acute myocardial infarction (AMI) before and after treatment, and the incidence of severe ventricular arrhythmia. Methods: Fifty-five AMI patients were divided into treatment group and control group by randomized single-blind method. The QTd and QTcd before and after treatment and the incidence of severe ventricular arrhythmia in both groups were determined. Results: Before and after treatment, QTd and QTcd were significantly decreased (all P <0.01). The incidence of severe ventricular arrhythmias in the treatment group was 10.3% (3/2 9), significantly lower than 34.6% (9/2 6, P <0.05) of the control group. Conclusion: The combination of Puerarin and Polaroid fluid can reduce the incidence of QTd and severe ventricular arrhythmias in AMI patients.